Based in Allen, TX, 1ClickChemistry, Inc. specializes in custom chemical synthesis and R&D services. The company provides a diverse catalog of chemical building blocks, including click chemistry reagents, PEG products, and amino acids, serving various scientific and industrial clients.
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Toll Chemical Manufacturers
Last updated: January 2026
This directory lists 110 toll chemical manufacturers across the United States, from specialty chemical blenders and compounders to advanced custom synthesis houses and hazardous material processors.
Buyers often arrive here trying to solve critical challenges like managing fluctuating demand for a proprietary blend, needing access to specialized equipment for a complex multi-step synthesis, or requiring expertise in handling hazardous raw materials and their associated waste stream management. They are looking to leverage external capacity without the significant CAPEX of building new infrastructure.
Suppliers in this space range from large, multi-site enterprises offering extensive capabilities like fractional distillation and large-scale polymerization, to smaller, more agile regional facilities specializing in specific unit operations such as high-shear mixing or solvent recovery. Distinctions often lie in their permitted capabilities, reactor sizes, hazardous area classifications, and vertical integration into specific end markets like pharmaceuticals or agriculture.
Company Directory
110 companies nationwide
Based in Dallas, Texas, Aceschem Inc. manufactures pharmaceutical intermediates and fine chemicals. The company provides custom synthesis, Contract Research Organization (CRO), and Contract Manufacturing Organization (CMO) services. Capabilities include process development from lab to bulk quantities.
Based in Forest Hill, TX, Advanced Blending specializes in toll blending and private label manufacturing of liquid and dry/powder chemicals. They offer comprehensive services including chemical blending, repackaging bulk materials, and raw material sourcing. The company utilizes multiple blending vessels.
AgroChem USA is a custom toll chemical manufacturer, providing specialized formulations and solutions for clients. The company offers direct toll production services to meet diverse client needs for chemical solutions, alongside its own line of advanced chemical hygiene products for the dairy industry. It focuses on delivering tailored chemical manufacturing.
Based in Houston, TX, ALLCHEM Chemical Blending offers custom toll blending and packaging services for liquid and dry chemicals. The company utilizes ribbon blenders and various packaging equipment, handling blend sizes from pilot batches to large production runs. Services include quality control and specialized projects.
Based in Buena Park, CA, Allied International specializes in custom industrial liquid and powder chemical manufacturing. They provide toll blending, filling, and packaging services for industrial, food service, automotive, and laundry industries. The company operates an EPA registered 30,000 square foot facility.
Based in Mt Holly, NC, ArroChem Inc. specializes in full-service private label chemical solutions. They provide comprehensive chemical manufacturing, blending, and packaging services, empowering clients to market products under their own brand. This allows businesses to focus on their core growth strategies without the complexities of production.
Based in Houston, TX, Ashburn Chemical Technologies specializes in industrial fluid and chemical solutions for metalworking and facility protection. They provide a range of products, including coolants, cleaners, and lubricants. The company also offers private labeling services, enabling clients to brand and sell products under their own name.
Based in Frisco, TX, Aurum Pharmatech Inc. specializes in custom and chiral chemical synthesis for pharmaceutical and research needs. They develop novel life-science reagents, including anticancer agents and kinase inhibitors. The company also provides unique building blocks, scaffolds, and PEGylation reagents to support diverse drug discovery processes.
Based in Medina, OH, Avion Manufacturing specializes in non-hazardous toll blending, private label manufacturing, and packaging of both liquid and dry chemicals. The company also provides high-quality replacement parts and multiple stop-off coatings for the heat treat industry, serving a global customer base.
Based in San Diego, CA, AxisPharm provides expert custom synthesis for small molecules, biologics, and specialty chemicals, including ADC linkers, bio-labeling reagents, and fluorescent dyes. The company offers customized bioconjugation services and analytical support for biotech and pharma R&D projects.
Based in Lewisville, TX, Bio-Synthesis Inc. specializes in custom chemical synthesis services for biomolecules. The company offers multigram synthesis of DNA, RNA, and ultra-long peptides. Capabilities include comprehensive modifications, biomolecular conjugation, gene expression vector production, and custom cloning services.
Based in Alvin, TX, BlendPack LLC specializes in customized chemical blending, formulating, manufacturing, and packaging services. They offer comprehensive repacking from bags to bulk, custom labeling, and various wrapping options. Their facility includes certified truck scales and warehousing, strategically located near major Houston, Texas ports.
Bomar provides cost-efficient toll manufacturing solutions for raw materials, specializing in the development and manufacture of UV/EB oligomers, resins, coatings, and additives. These high-performance polymeric materials support global formulators across applications such as 3D printing, nail coatings, and industrial coatings.
Based in Cadet, MO, Buckman offers custom manufacturing services, including tolling and blending, for various chemical solutions. Their expertise encompasses microbial control, water clarifiers, dewatering aids, emulsion breakers, coagulants, and flocculants, specializing in advanced water treatment for industrial applications.
Based in San Diego, CA, CalChem Synthesis is a Contract Research Organization (CRO) providing custom synthesis, medicinal chemistry, process research, and scale-up services. They serve biotech and pharmaceutical companies, and research institutions as an outsourcing partner for non-GMP chemistry.
Capital Resin Corporation offers custom chemical contract and toll manufacturing services for customer-formulated and specialty chemicals. They provide chemical blending, bulk storage, and packaging for industrial resins like phenolic and amino resins. The company also supports process development and contract research for diverse industries.
Based in Ann Arbor, MI, Cayman Chemical specializes in custom organic synthesis and contract development and manufacturing (CDMO) services. Their expert chemists perform complex, multi-step organic syntheses, offering process development, analytical services, and GMP manufacturing for novel and existing compounds, from milligram to multi-kilogram scales.
Based in Round Rock, TX, Cerilliant specializes in custom chemical synthesis, including heterocyclic chemistry, opiates, cannabinoids, steroids, thiols, and peptide/amino acid synthesis. The company expertly crafts high-quality certified reference materials for forensic, clinical, pharmaceutical, nutraceutical, and environmental testing and research applications.
Based in Marinette, WI, ChemDesign Products, Inc. is a custom toll chemical manufacturer of agricultural, fine, and specialty chemicals. The company operates an advanced processing site with technical staff and well-equipped facilities, focusing on quality assurance, safety, and reliability.
Chemical Process and Production Inc. specializes in toll distillation, providing high-performance solutions for hydrocarbon processing along the Gulf Coast. Their core competency includes stream polishing for purifying and recovering valuable intermediates from co-product and bi-product streams, offering flexible solutions for petrochemical challenges.
Based in Cleveland, OH, Chemical Solvents offers direct toll manufacturing and custom blending services for a wide range of solvent and aqueous chemical blends. They utilize versatile blending equipment to provide outsourced solutions for increased capacity. The company also distributes commodity chemicals and provides waste management services.
Based in Burlingame, CA, ChemShuttle provides a range of chemistry services, including custom synthesis from milligram to kilogram scales. They specialize in multi-step synthesis (1-10+ steps) for intermediates and chemical libraries, along with FTE chemistry services for research and development needs.
Based in Valdosta, GA, CJB Applied Technologies provides independent contract formulations development and pilot plant services. They specialize in scale-up and pilot plant production, assisting clients in bridging the gap between laboratory-scale development and full commercial manufacturing. Their services support various markets and industries.
Columbus Chemical Industries, with facilities in Columbus, WI and Phoenix, AZ, specializes in contract manufacturing, custom blending, and chemical processing. They provide customized, high-purity chemical solutions for diverse industrial sectors, including semiconductor, medical device, energy, and biotech, with comprehensive packaging services.
Based in North Kansas City, MO, CUI Solutions is a family-owned custom chemical manufacturing company. They specialize in high-performance cleaning solutions, offering private branding and custom chemical blending for janitorial, food service, and industrial distributors. With low minimums, CUI Solutions provides full-color label printing and quality products.
Based in Fresno, CA, Custom Ag Formulators, Inc. offers toll blending and manufacturing services for the agricultural chemical industry. With extensive experience, they specialize in custom formulating and packaging a wide range of ag products. The company operates facilities in both California and Texas.
Based in Santa Fe Springs, CA, Custom Chemical Formulators, Inc. provides chemical blending services with over 50 years of experience. They specialize in contract manufacturing, private labeling, and custom product development. The company offers large-scale production capabilities, serving diverse industries across the US.
Based in Pasadena, TX, Dixie Chemical Company manufactures high-performance specialty chemicals, handling complex chemistries. With extensive lab capabilities and a history since the 1940s, the company focuses on open innovation. It develops new chemical products for various project sizes.
Based in Houston, TX, Economy Polymers & Chemicals provides comprehensive toll manufacturing and custom chemical blending services. With over 70 years of experience, they offer precise blending, grinding, and pulverizing for diverse industries including oil & gas, food, personal care, and water treatment, ensuring consistent quality.
Based in Tuckahoe, NY, Elcan Industries Inc. offers advanced toll sieving and separation services for powdered materials. Operating a state-of-the-art contract manufacturing facility, the company specializes in processing various powders down to fine particle sizes, providing expert solutions for industrial clients.
Based in The Woodlands, TX, Element Chemicals manufactures custom chemical solutions for energy and water treatment. They leverage in-house R&D and a full-service lab for corrosion, flow assurance, and scale testing. The company designs, tests, and manufactures products to keep customer operations running smoothly.
Based in Auburn, WA, Formula Corp provides contract and toll custom chemical manufacturing and blending services. Utilizing its state-of-the-art, ISO-certified facility, the company specializes in custom blending and packaging a wide range of products for personal care, household, industrial, and institutional clients.
Based in Logan, UT, Frontier Specialty Chemicals provides custom synthesis services and a catalog of thousands of high-quality chemical compounds. Their skilled chemists perform syntheses at their US facility, supporting critical research projects and shipping globally to customers.
Genesis Chemical & Blending is an EPA registered facility specializing in toll manufacturing and custom chemical blending. They provide advanced liquid blending capabilities, serving as an extension of client operations. The company offers chemical solutions for agrochemicals, oil and gas downstream programs, and industrial water treatment industries.
Based in Columbus, OH, GFS Chemicals, Inc. is an ISO 9001:2015 certified U.S. manufacturer of fine and specialty chemicals. The company provides custom inorganic chemical manufacturing services, synthetic organic technology, and produces analytical reagents. They also supply alkyne building blocks for diverse commercial applications.
Harcros specializes in chemical toll manufacturing, offering comprehensive services for custom chemical production and blending. With over a century of experience, the company provides solutions to clients across various industries in the United States and worldwide, delivering specialized manufacturing expertise and capabilities.
Based in Brookfield, WI, Hydrite Chemical is a direct provider of toll chemical manufacturing services. The company specializes in custom blending, tolling, and contract manufacturing, supported by dedicated R&D and technical service staff to solve challenging issues for its clients.
Based in Carson, CA, Jayne Products is a formulator and manufacturer of environmentally friendly chemical cleaning products. The company specializes in the oil, wastewater, and transportation industries, providing specialty products and technical assistance. They also offer industrial descalers, deodorizers, and chemical blending services.
Based in Corpus Christi, TX, J&J Tamez LLC offers custom chemical blending services for the oil and gas industry. They utilize advanced chemical mixing plants, including "Smart Unit" and "Hybrid Unit" models, to develop tailored chemical recipes. The company specializes in optimizing performance with solutions like brine-tolerant chemicals.
Based in Houston, TX, Lubchem provides custom chemical toll blending and private label services. The company processes complex chemical formulations, including drilling fluids, for industrial applications. Lubchem also manufactures industrial lubricants, valve sealants, and cleaners, primarily serving the oilfield, pipeline, refining, and petrochemical industries.
Mark V offers custom chemical formulation and private label blending services for various industries. With over 50 years of experience, the company develops and manufactures chemical products, including concentrated detailing supplies for auto, marine, air, and home applications, in the United States.
McGean provides custom and toll manufacturing services for chemical reaction processing, formulated products, and blending of liquids and solids. The company operates facilities in Ohio and Michigan, offering expertise in specialty organic and inorganic chemistries for various industrial applications.
MFG Chemical provides custom chemical manufacturing services, guiding products from ideation to full-scale production. Specializing in a wide range of chemistries, they utilize upgraded plant and pilot testing facilities. They serve markets including agriculture, energy, and personal care.
Miles Chemical Company, based in Arleta, CA, specializes in liquid and dry chemical blending as a core supply chain service. They also offer extensive chemical distribution, 3rd Party Logistics, and environmental services. Serving diverse industries like metal manufacturing, electronics, food & beverage, and personal care, Miles Chemical operates facilities in Arleta and Anaheim.
Based in The Woodlands, TX, Mission Chemical offers comprehensive toll and contract chemical manufacturing services. Utilizing extensive in-house facilities and laboratory assets, they also provide custom blending and packaging. The company serves diverse B2B clients.
Based in Houston, TX, Modern Chemical Co. is a bulk chemical distributor and supplier specializing in expert chemical contract manufacturing and bulk toll manufacturing services. They offer capabilities for both liquid and powder substances, including blending, custom manufacturing, and bulk liquid trans-loading.
Moravek, based in Brea, CA, is a contract development and manufacturing organization (CDMO) offering radiosynthesis services. The company specializes in custom organic synthesis for carbon-14 and tritium labeled compounds, including GMP active pharmaceutical ingredients (APIs) for early phase clinical trials and non-GMP research compounds.
Nippon Chemical Texas Incorporated (NCTI), based in Pasadena, TX, is a specialty chemical manufacturer and part of ENEOS Corporation. NCTI produces Ethylidene Norbornene (ENB) and Specialty Aromatic Solvents (SAS) for various industrial applications. They also offer custom chemical manufacturing services, developing new formulations for specific client needs.
Based in Bensalem, PA, NJonas is a chemical manufacturer specializing in private labeling for professional pool and spa companies nationwide. The company provides a complete private labeling system, enabling clients to sell their exclusive brands of pool and spa chemicals, and consistently develops new products.
Based in San Antonio, TX, Noah Chemicals manufactures specialty and high-purity chemicals. They offer chemical services including custom synthesis, purification, particle size reduction, calcination, and combustion for client formulations. The company produces a wide range of inorganics, metal salts, and pharmaceutical intermediates.
Based in Granville, OH, Prime Solutions offers chemical contract manufacturing and packing. They specialize in liquid and powder toll blending, private labeling, and custom formulating. Services cover HazMat and flammable materials, co-packing, chemical warehousing, and inventory management, with ISO 9001:2015 certification.
Based in Brenham, TX, Quest Specialty manufactures a wide range of specialty maintenance chemicals. The company offers custom formulations and contract packaging for aerosols, liquid concentrates, liquid RTU, powders, and wipes. Their product lines include cleaners, degreasers, lubricants, and insecticides for various B2B applications.
Based in Lower Gwynedd, PA, Richman Chemical Inc. provides a full range of custom synthesis and US-based manufacturing services. They offer chemical production capabilities, catering specifically to companies within the life science and broader chemical industries, delivering specialized solutions for their manufacturing needs.
Based in Orlando, FL, RMA Ravago Manufacturing provides tolling capabilities and compounding services for various polymers, including polyolefins and styrenics. They utilize extensive facilities and equipment to meet diverse product and process requirements, serving both industrial producers and direct consumers with reliable chemical solutions.
Royal Chemical Company, based in Macedonia, OH, is a custom chemical contract manufacturer with five U.S. plants. They specialize in toll blending for liquids and powders, serving diverse industries. Services encompass blending, packaging, precision bottling, warehousing, and logistics solutions, supporting consistent, high-quality product delivery.
Based in Lake City, MN, RTP Company offers toll compounding services for custom engineered thermoplastics. They provide solutions and customization, utilizing a wide range of resins and modifiers to create specialty compounds. Products include pellets, sheet, and film, serving industrial sectors like medical applications.
Based in South Bend, IN, Sandstrom Products Company provides toll services for coating and adhesive manufacturers. They specialize in building dry film lubricants and unique coating products for aerospace, defense, and high-performance industrial markets, leveraging decades of expertise.
Schirm USA, Inc. is a chemical toll manufacturer operating as a neutral, non-compete site. The company provides comprehensive formulation, packaging, and warehousing services for a wide range of products including liquids, powders, and granules. They serve diverse industries such as oil and gas, industrial additives, and construction chemicals.
Based in Rosenberg, TX, Seatex LLC is a specialty chemical technology manufacturing solutions company. They offer custom manufacturing, liquid and dry blending, grinding, and milling services. Seatex provides custom packaging capabilities from one gallon to rail car for various chemical products, including cleaners, disinfectants, and degreasers.
Snyder Manufacturing provides chemical blending, formulation, and filling services for liquid and powder products. With three generations of expertise, the company operates high-speed filling lines in California and Texas, accommodating containers from 2 oz. It offers tailored blending solutions for diverse client needs.
Based in Adelanto, CA, Specialty Organics, Inc. provides custom synthesis and chemical contract/toll manufacturing services. The company offers pilot plant facilities for scaling up laboratory processes and on-site quality control. They serve various industries, including plywood and furniture, with high-quality chemical products and solutions.
Based in Valencia, CA, Specialty Polymers & Services, Inc. is a custom formulator and specialty packager of advanced materials. They provide adhesives, coatings, sealants, and encapsulates for aerospace, electronics, and industrial applications. The company also serves as a multi-line distributor for these specialized chemical products.
Based in Houston, TX, Sunita Hydrocolloids Inc., USA provides specialized toll blending and custom formulation services for the oil and gas industry. They manufacture a range of oilfield chemicals, including guar-based gelling agents, crosslinkers, clay stabilizers, and defoamers, serving North and South American markets.
Sunland Chemical & Research Corporation provides comprehensive toll manufacturing, custom chemical blending, bottling, and hazmat warehousing services. Based in Los Angeles, CA, they utilize a state-of-the-art laboratory for quality assurance. The company specializes in handling acids, biocides, solvents, and other chemical compounds, offering expert production and handling solutions.
Based in Cleburne, TX, Technical Chemical Company provides comprehensive private label chemical manufacturing and packaging services. They enable customers to brand a wide range of their chemical products with their own name, offering solutions from formulation to finished goods for various industrial and commercial needs.
Based in Houston, TX, Third Coast specializes in contract chemical manufacturing, drawing on over 20 years of experience. They utilize specialized reactors and their facilities to produce specialty chemicals to exact customer specifications, also offering extensive packaging and efficient product handling services.
Based in Norwood, NJ, Tilley Distribution offers specialty chemical blending, custom formulation, and manufacturing assistance. They provide bespoke solutions and high-quality ingredients for diverse industries, including industrial, food & nutrition, personal care, and healthcare & pharma sectors.
Toll Compaction is a contract manufacturer specializing in powdered chemicals, polymer additives, nutritional products, and functional foods. The company provides services including blending, dry granulation, size reduction, screening, pelletizing, and comprehensive packaging solutions for various materials.
Tosoh offers custom chemical synthesis services, specializing in active pharmaceutical development with both GMP and non-GMP capabilities. Leveraging a team of fifty highly skilled R&D scientists, the company provides expert chemical manufacturing solutions. Their focus is on complex synthesis for diverse industrial and pharmaceutical clients.
Based in Dalton, GA, TRCC offers contract and custom toll manufacturing services for specialty chemicals. The company provides innovative solutions and technical services, investing in R&D for advanced chemical processes and materials. TRCC serves diverse markets like carpet, flooring, healthcare, and oil & gas.
Troy Chemical, based in Burton, OH, is an ISO-certified manufacturer specializing in toll blending and private label manufacturing. The company provides concentrated chemistries including pretreatment chemicals, metalworking fluids, and wastewater solutions for the surface finishing industry.
Vantage Specialty Chemicals specializes in custom formulations and tailored solutions for consumer and industrial markets. Utilizing vertically integrated manufacturing assets, the company delivers over 2000 formulated products and specialty components. Its core expertise includes bio-based surfactant chemistry, derived from natural oils, seeds, and botanicals, focusing on customization and optionality.
VRC Technologies Inc., based in Brownwood, TX, specializes in toll blending and chemical reaction capabilities. The company provides chemical storage, handling, and integrated logistics for the oil & gas, agriculture, and chemicals industries, offering custom manufacturing with a focus on quality and responsive supply chain.
Based in Nashua, NH, Worthen Industries provides toll manufacturing services, including custom polymerization and toll compounds & solutions. The company also manufactures specialty adhesives, coatings, coated flexible substrates, and thermoplastic extrusion for diversified markets. They focus on sustainable innovation through responsible manufacturing and a customer-first approach.
Based in Elkhart Lake, WI, American Blending Company specializes in toll blending and custom manufacturing of dry powder and liquid chemicals. They provide private label manufacturing and packaging services, offering comprehensive solutions from product development to final delivery for diverse industrial clients.
Anatrace specializes in custom chemical synthesis and the manufacturing of high-quality reagents, particularly for membrane protein studies. Based in San Clemente, CA, the company operates through its subsidiary, BioCoomer, providing specialized chemical production services for research and industrial applications.
Based in Princeton, NJ, NJ Bio, Inc. specializes in custom chemical synthesis services, crafting unique compounds, small molecules, and specialty chemicals. With facilities in New Jersey and Pennsylvania, the company offers tailored chemical manufacturing processes for a range of client specifications.
Scimplify is a US-based specialty chemical manufacturer providing R&D and large-scale manufacturing services. The company focuses on integrating research and development with commercial production for complex chemical development across various industries.
Based in Stanton, CA, Ultra Clean Chemicals provides toll chemical manufacturing services. The company specializes in custom private labeling for customers needing bespoke branded chemical products. They offer duplication of existing labeling and custom packaging solutions, helping clients market products under their own brand.
Based in Odessa, TX, West Texas Blending provides custom chemical toll blending and manufacturing services. They offer liquid and dry blending, serving the Permian Basin with ISO 9001 certified precision. The company focuses on reducing shipping costs and ensuring on-time deliveries for its clients.
Based in San Diego, CA, Advanced Synthesis provides custom chemical manufacturing services. They specialize in organic custom synthesis, chemical synthesis of small organic molecules, and process research and development with scale-up capabilities. Services include custom distillation and extraction from natural sources, supporting projects from bench to pilot scale.
Based in Stoughton, MA, Alpha Chemical Services, Inc. specializes in private label chemical manufacturing. They produce custom formulations and private label solutions as powders, liquids, and solids for diverse sectors, including commercial cleaning, automotive, laundry, food processing, and restaurant/kitchen industries. The company is ISO 9001:2015 certified.
Based in Agawam, MA, Applied Chemistries provides industrial chemical formulating services. The company offers a wide range of chemical formulation solutions, including specialized services for printing applications.
Based in Hanover, PA, AquaPhoenix Scientific manufactures ACS grade starting materials and various testing reagents. The company offers private label chemical and reagent manufacturing services, alongside custom private labeling for test kits and equipment. They also provide comprehensive smart water and chemical management solutions, including technology and control equipment.
Bio-Edge specializes in custom chemical production services for medical and industrial applications. Based in San Diego, CA, the company offers small-batch synthesis and R&D support for various chemical compounds.
Based in Stony Brook, NY, BOC Sciences provides custom synthesis services for intermediates, APIs, and specialty chemicals. They manufacture high-purity small-molecule inhibitors, pseudoUridine, and biograde nucleosides/nucleotides to research-grade or GMP-compliant specifications, supporting diverse research and industrial applications.
Based in Florence, KY, Camco Chemical is a contract manufacturer and fulfillment provider specializing in powder and liquid chemical products. They offer comprehensive services including chemical liquid and powder blending, packaging, warehousing, order fulfillment, sourcing, procurement, and bulk handling, simplifying the supply chain for various industries.
Based in Houston, TX, ChemOrganics offers comprehensive reaction synthesis services, supporting contract manufacturing campaigns. The company provides capabilities from pilot scale to commercial production, serving as a partner in specialty chemical manufacturing for various industrial clients.
Colonial Chemical Inc., based in South Pittsburg, TN, specializes in the contract manufacturing of sustainable surfactants and specialty ingredients. The company utilizes its state-of-the-art facilities to produce a diverse range of chemical products for various industries, offering custom synthesis capabilities for client-specific needs.
Based in Rocklin, CA, CPC Scientific is a Contract Development and Manufacturing Organization (CDMO) specializing in synthetic peptide manufacturing. The company produces custom peptides with diverse modifications, serving clients requiring specialized chemical synthesis. They leverage their expertise to deliver high-quality, tailored peptide solutions for research and industrial applications.
Based in Rancho Dominguez, CA, Crossfield Products Corp. provides contract manufacturing, private label, and toll blending services for various chemical products. The company specializes in blending chemicals to customer formulas with strict confidentiality. They utilize over 80 years of manufacturing experience, also producing specialty materials for construction coatings and flooring.
Cymer Chemicals, based in Decatur, TN, is a custom chemical and toll manufacturer specializing in organic chemistries. They produce fine and specialty chemicals, including monomers, resins, and sealants, for diverse industrial markets like adhesives, aerospace, batteries, and coatings. Their experienced team offers manufacturing services.
Based in Countryside, IL, Nyco Products Company manufactures cleaning chemicals, disinfectants, and floor care products. The company offers private label chemical branding and custom formulation services. It serves distributors and facility maintenance professionals for industrial and institutional cleaning applications.
Based in Powell, OH, Ohio Peptide specializes in custom peptide synthesis and manufacturing for research and drug discovery. They provide high-quality catalog and custom peptides, API, bulk chemicals, intermediates, and contract research services. With manufacturing capabilities from milligram to kilogram scale, they serve academic and industrial organizations.
Based in Houston, TX, Riteks is an industrial chemical supplier offering custom manufacturing, blending, packaging, and repackaging services. They provide chemical solutions for diverse sectors including oilfield, construction, and protective coatings, helping clients meet specific requirements for their products.
Based in Houston, TX, South Coast Terminals provides specialty chemical manufacturing, terminal, and warehousing services. Established in 1964, the company operates as a custom chemical toll manufacturer, utilizing over 350 tanks across three Gulf Coast locations, focusing on reliable supply and customer solutions.
Based in West Sacramento, CA, Sierra Chemical Company offers chemical blending and product manufacturing services, including private label solutions. They provide proven formulations for agricultural, cleaning, pool & spa, food service, technology, and industrial applications, serving diverse B2B markets since 1946.
Based in Hebron, OH, State Contract Manufacturing provides contract chemical blending, private labeling, and custom packaging services. The company offers professional formula and process development, alongside material sourcing, to meet diverse chemical manufacturing needs for its clients.
State Industrial Products provides full-service contract manufacturing, specializing in liquid and powder blending for chemical solutions. They offer custom packaging, labeling, and fulfillment, along with advanced R&D support. The company serves industrial clients, delivering smarter solutions for cleaner, more organized operations.
Based in Alachua, FL, SynQuest Laboratories, Inc. provides custom synthesis and bulk chemical manufacturing services. They utilize complex processes to produce over 5,000 chemicals, proficiently handling hazardous liquids, gases, and solids. The company supports client research, scale-up, and commercial requirements with skilled scientists and global sourcing.
Based in Pipestone, MN, Synsus Private Label Partners produces specialty chemicals for agriculture, turf & ornamental, and industrial cleaner markets. They offer comprehensive private label services, including custom chemical formulation, raw material sourcing, manufacturing, packaging, and delivery. Products include nitrogen stabilizers, micronutrients, biostimulants, and colorants.
TOKAmerica specializes in the custom manufacturing of chemical reagents, including highly corrosive and hazardous materials, with over 20 years of experience. They provide toll manufacturing services alongside their products for the semiconductor and medical device industries. Operating US facilities in Oregon and California, the company offers comprehensive chemical production capabilities.
TransChemical provides value-added blending services for chemicals, flammables, and food ingredients, specializing in product customization. The company offers comprehensive supply, distribution, and packaging solutions. Located in the heartland of America, TransChemical supports industrial clients with efficient delivery of bulk and packaged chemicals.
Based in The Woodlands, TX, Trecora is a U.S. manufacturer providing high-purity specialty custom chemical processing solutions. They produce hydrocarbons, specialty waxes, and lubricant additives for various industrial applications. The company leverages its manufacturing facilities to offer tailored chemical production services to clients.
ALTIVIA specializes in toll chemical manufacturing and custom phosgenation services. Operating facilities across Texas, West Virginia, and Ohio, the company produces a range of petrochemicals, ketones, and phosgene derivatives. ALTIVIA offers tailored chemical formulations and consistent results for critical industries, emphasizing reliable operations.
Miscoproducts is a cleaning chemical manufacturer specializing in private labeling and private branding services. The company develops and produces a wide range of cleaning chemicals for other businesses, leveraging over 1600 proprietary formulas. They offer contract manufacturing solutions, enabling clients to market custom-branded chemical products under their own brand.
Optima Chemical offers full-service chemical manufacturing and toll services from its two US plants. They provide custom chemical solutions for partners, specializing in high-energy and hazardous chemistry. The company serves diverse markets including electronics, energy storage, catalysts, polymers, and pharmaceuticals.
Headquartered in Cincinnati, OH, Pilot Chemical is a specialty chemical manufacturer offering extensive toll and contract manufacturing services. They utilize proprietary technologies for alkylation, sulfonation, sulfation, amidization, esterification, polymerization, blending, and custom formulation. The company serves diverse industrial, household, personal care, and oil & gas markets.
Thermo Fisher provides custom-made solvent and aqueous blends through its dedicated chemical mixing facilities. The company prepares bespoke chemical formulations, helping clients in the life sciences, biotech, and pharmaceutical sectors achieve consistency and efficiency. Their services support processes from initial discovery to commercialization.
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How to Choose a Company
- Verify Process Capabilities: Confirm they possess the specific reactor types (e.g., glass-lined, Hastelloy), pressure/temperature ranges, and auxiliary equipment like centrifuges or filtration systems required for your specific reaction kinetics and desired product purity, not just general "synthesis" capability.
- Assess Regulatory Compliance & Certifications: For regulated end markets, demand proof of specific registrations like FDA (e.g., for APIs or food additives), EPA (for TSCA-regulated substances), or adherence to cGMP protocols, along with robust Process Hazard Analysis (PHA) and HAZOP studies.
- Evaluate Scale-Up Expertise: Don't just look at maximum batch size; scrutinize their track record and methodology for successful scale-up validation from pilot to commercial production, including analytical method transfer and yield optimization, especially for novel chemistries.
- Watch for Hidden Waste Stream Costs (Red Flag): A common pitfall for new buyers is underestimating the true cost of waste stream management. Ensure your quoted price explicitly details disposal fees for all byproducts, solvents, and off-spec materials, especially for hazardous waste, to avoid significant surcharge surprises.
Frequently Asked Questions
What are the key differences between a toll blender and a custom synthesis manufacturer?
A toll blender typically focuses on combining existing raw materials to create a formulation, often involving mixing, compounding, and repackaging, without fundamental chemical reactions. A custom synthesis manufacturer, conversely, performs chemical reactions to create new molecular structures or complex intermediates from simpler precursors, requiring deeper chemical engineering expertise and more specialized reactor systems.
How can I ensure intellectual property (IP) protection when sharing my proprietary formulations or process details with a toll chemical manufacturer?
Robust Non-Disclosure Agreements (NDAs) and specific Intellectual Property Agreements (IPAs) are paramount. These contracts should clearly define ownership of the formulation, process improvements, and any new IP generated during the tolling arrangement. Additionally, verify their internal data security protocols and employee confidentiality policies, especially when dealing with highly sensitive custom synthesis projects.
What critical documentation should I expect from a toll manufacturer for each production batch?
For each batch, expect a detailed Certificate of Analysis (CoA) confirming product specifications, a Certificate of Conformance (CoC), and a comprehensive batch record that meticulously documents all raw material inputs, process parameters (e.g., temperatures, pressures, hold times), in-process analytical results, and any deviations. Depending on the product and regulatory requirements, you might also require Safety Data Sheets (SDS) and full lot traceability records.