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Custom Chemical Manufacturers

Last updated: January 2026

This directory lists 89 custom chemical manufacturers across the United States, from formulation specialists to turnkey contract manufacturers.

Buyers in this specialized field are typically solving critical problems such as achieving commercial-scale production of a proprietary molecule, optimizing a multi-step organic synthesis to improve purity and yield, or formulating complex blends for specific applications like agrochemicals or personal care. Success hinges on a partner's ability to not only execute a defined process but also to provide value-added services like process development, analytical method validation, and managing specialized reaction pathways such as high-pressure hydrogenation or cryogenic reactions.

The custom chemical manufacturing ecosystem encompasses a variety of supplier types, from contract development and manufacturing organizations (CDMOs) that offer comprehensive drug substance development from discovery to commercialization, to specialty chemical custom synthesizers focused on niche industrial intermediates or fine chemicals. You'll also find dedicated toll blenders and formulators who specialize in mixing and packaging established formulas, distinct from those performing complex, proprietary reaction chemistry. Understanding the specific expertise and equipment footprint of each type is crucial for a successful engagement.

89 companies·68 emails·80 phones

Company Directory

89 companies nationwide

3V Sigma USA is a global chemical manufacturing company specializing in the formulation and production of advanced specialty chemicals. The company provides contract and toll manufacturing services, personal care product development, and laboratory testing. They serve various industries with high-performance synthetic polymers and organic chemistry molecules.

Forest Hill, TX

Based in Forest Hill, TX, Advanced Blending manufactures liquid and powder chemicals for various industries. They specialize in toll blending, private label manufacturing, and packaging services. The company also offers raw material sourcing, fulfilling needs from short runs to multi-truckload contracts.

Houston, TX

Based in Houston, TX, AES Chemicals provides custom chemical solutions, emphasizing speed, precision, and customer-centricity. Their services include manufacturing, toll blending, chemical blending, private labeling, and lab testing. They tailor processes to meet unique client needs across various industries, delivering efficient, high-quality solutions.

Saratoga Springs, NY

Based in Saratoga Springs, NY, AgroChem USA provides contract and toll manufacturing services for chemical solutions. They serve diverse industries such as dairy, agrochemical, wastewater, personal care, brewery, and laundry. Their offerings include cleaners, sanitation products, and specialty chemical formulations for commercial clients.

Houston, TX

Based in Houston, TX, Allchem Services specializes in dry and liquid custom toll blending and packaging for various chemicals. They offer dedicated systems for specialized projects, custom labeling, and quality control services with a chemist on staff. Capabilities include blending batch sizes from 10 lbs to 15,000 lbs.

Buena Park, CA

Allied International, based in Buena Park, CA, specializes in custom chemical manufacturing and packaging. They offer chemical formulation, contract blending, and re-packaging for both liquid and powder/granular products. Serving industries such as laundry, food service, industrial, and automotive, they handle diverse viscosities and pH levels.

Alvin, TX

Based in Alvin, TX, Allied Petrochemical specializes in custom chemical manufacturing, tolling, and contract manufacturing services. Since 2000, they have provided chemical solutions for industrial and commercial clients, including Fortune 500 companies. Their facility supports diverse chemical production needs, offering reliable processing for various chemical products.

Norwalk, CA

Based in Norwalk, CA, American Blending Company specializes in toll blending, custom manufacturing, private label manufacturing, and packaging of dry powder and liquid chemicals since 1985. They offer onsite quality control, are DOT Haz Mat registered, and ISO Certified 9001:2015, signing non-disclosure agreements with all customers.

Mt Holly, NC

Based in Mt Holly, NC, ArroChem Inc. specializes in custom chemical manufacturing and blending services. The company provides tailored chemical solutions for a wide range of industrial markets. They focus on delivering specific formulations to meet client needs.

South Charleston, WV

Based in South Charleston, WV, AVN Corp specializes in custom and specialty chemical manufacturing. The company operates small-scale production facilities for low-volume chemicals, offering comprehensive services from R&D and pilot plant scale-up to commercial production, supporting both batch and continuous operations.

Rialto, CA

Based in Rialto, CA, California Chemical Specialties manufactures custom chemical products for other manufacturers. They specialize in powders, liquids, gels, and gel polish accessories, along with various chemical treatments, catering to industrial B2B clients with minimum order volumes.

California Chemical provides custom chemical manufacturing and blending services. They offer precision formulation services, GMP-compliant facilities, custom packaging solutions, and scalable production capabilities for various industrial applications, specializing in tailored chemical products.

Columbus, OH

Based in Columbus, OH, Capital Resin Corporation is a custom chemical manufacturer specializing in contract and toll manufacturing. They provide chemical blending, process development, and research capabilities to produce industrial resins and chemicals, including phenolic, amino, and resorcinol resins.

Vernon, CA

Based in Vernon, CA, C.C.I. Chemical Corporation manufactures custom-blended chemical solutions in its own facilities. They provide industrial chemicals for diverse applications, including wastewater and water treatment programs, proprietary cleaners, and USDA approved formulas for the food industry.

Pearland, TX

Based in Pearland, TX, Custom Chemicals and Coatings LLC manufactures custom industrial coatings and specialty chemicals. They offer Zero VOC, quick-dry, low-emissions, and chemical-resistant formulations including epoxies, urethanes, primers, and top coats. They also provide surface preparation chemicals for the oil and gas and general industrial sectors.

Zellwood, FL

Based in Zellwood, FL, Chemical Systems provides custom chemical contract manufacturing with over 40 years of experience. Services include blending client formulas, custom product formulation, private labeling, and new product development. They manage production from design to final delivery, supported by high-volume blending equipment and an on-site quality assurance laboratory.

Phoenix, AZ

Columbus Chemical Industries provides contract manufacturing, blending, and compounding of chemicals from facilities in Phoenix, AZ, and Columbus, WI. They specialize in high-purity blends for the Semiconductor, Food, Pharma, and Medical Device industries, also serving various industrial and commercial applications with toll blending and custom solutions.

Garland, TX

Based in Garland, TX, Corrosion Technologies provides turnkey toll blending and custom chemical manufacturing solutions. They offer product formulation, blending, private labeling, packaging, warehousing, and global shipping services. Clients benefit from their technical expertise, specialized equipment, and flexible production capabilities for various chemical product needs.

North Kansas City, MO

Based in North Kansas City, MO, CUI Solutions is a family-owned custom chemical manufacturer. They provide private branding and custom chemical blending for high-performance cleaning solutions. Serving janitorial, food service, and industrial distributors, the company offers tailored products with low minimums.

Santa Fe Springs, CA

Based in Santa Fe Springs, CA, Custom Chemical Formulators, Inc. offers chemical blending, contract manufacturing, private labeling, and custom product development. With over 50 years of experience, their expert chemists and large-scale facility serve diverse industries throughout the US.

Pasadena, TX

Based in Pasadena, TX, Dixie Chemical Company specializes in the development and manufacturing of high-performance specialty chemicals. Since the 1940s, the company has offered extensive lab capabilities for complex chemistries. They produce thermoset materials and smart materials, supporting diverse project scopes and sizes for customers.

Houston, TX

Economy Polymers and Chemicals, based in Houston, TX, provides comprehensive chemical toll manufacturing services. Their EPA-registered facility offers over 500,000 sq ft for blending custom liquid and powder products. Capabilities include powder grinding, blending, bottle filling, packaging, and distribution, accommodating diverse project sizes.

Tuckahoe, NY

Based in Tuckahoe, NY, Elcan Industries specializes in toll manufacturing services for various powders. Their capabilities include custom mixing and blending, toll screening, particle size analysis, and hammer milling. They process materials for industrial applications such as anode and cathode materials, ceramics, cosmetics, graphite, and pigments.

The Woodlands, TX

Based in The Woodlands, TX, Element Chemicals specializes as a wholesale chemical manufacturer for the energy and water treatment industries. The company offers customized chemical solutions, supported by an in-house R&D team and a full-service lab. They design, test, and manufacture products to keep operations running smoothly.

Auburn, WA

Based in Auburn, WA, Formula Corp provides custom chemical manufacturing and toll blending services. They produce custom chemical blends to client specifications, offering contract packaging and custom label design. The company supports West Coast contract manufacturing and distribution clients.

Batesville, AR

Based in Batesville, AR, FutureFuel Corporation specializes in custom chemical manufacturing. They partner with clients for complex chemical product development, leveraging expertise, engineering, facilities, and operational capacity. The company supports a broad range of chemical synthesis in both batch and full-scale continuous production.

Ennis, TX

Based in Ennis, TX, Genesis Custom Chemical Blending provides custom chemical blending solutions, including expert toll and liquid blending services. They manufacture fuel additives and wholesale chemicals, serving industrial clients in oil & gas, agriculture, and water treatment. The company operates across Texas and neighboring states.

Kansas City, KS

Based in Kansas City, KS, Harcros Chemicals provides custom and toll chemical manufacturing services. With over a century of experience, the company handles challenging and hazardous chemicals, adhering to all regulations. Harcros also offers chemical distribution, warehousing, and transloading services for various industries.

Grand Rapids, MI

Based in Grand Rapids, MI, Haviland Products Company provides custom chemical contract manufacturing services. They offer customizable solutions for diverse markets including automotive, agriculture, and animal health. Capabilities encompass design, liquid and powder blending, supply chain, filling, and packaging, supported by over 85 years of chemical manufacturing expertise.

Waller, TX

Based in Waller, TX, Houston Chemical provides chemical manufacturing services, including toll blending and chemical cleaning. They offer high-quality products to various industrial sectors such as oil and gas, agriculture, and construction across Texas and the entire USA for specific product lines like drilling fluids and chemicals.

Brookfield, WI

Based in Brookfield, WI, Hydrite Chemical is an ISO 9001:2015 certified manufacturer of custom and standard specialty chemicals. They offer custom blending, toll manufacturing, organic reactions, separation, and distillation services for diverse applications. Industries served include agriculture, energy, food & beverage, personal care, metal finishing, and electronics.

ICP Group manufactures a diverse range of specialized chemical products, including coatings, adhesives, and sealants. The company provides innovative solutions for customers across the United States and worldwide, utilizing its innovation centers to develop custom chemical formulations and advanced manufacturing capabilities.

Rock Hill, SC

Based in Rock Hill, SC, InChem provides comprehensive contract and toll chemical manufacturing services. They specialize in process development and scale-up, utilizing advanced equipment such as pilot plants, distillation units, batch reactors, and flaking capabilities. InChem also offers bulk storage and supply chain logistics.

Englewood, CO

Based in Englewood, CO, Innospec is a global specialty chemistry company providing custom chemicals, additives, and formulations. With manufacturing plants, they serve diverse markets including agrochemicals, construction, fuel, oilfield, personal care, and polymers. They develop fit-for-purpose, environmentally friendly ingredients for unique customer formulations.

Carson, CA

Based in Carson, CA, Jayne Products offers custom chemical manufacturing and toll blending services for liquid chemicals. They provide contract manufacturing, private label, and packaging solutions. The company assists with formulation improvements and raw material sourcing, supporting both short-term projects and long-term contracts.

St. Louis, MO

Based in St. Louis, MO, Jost Chemical Co. manufactures specialty chemicals, including ultra-pure minerals and microencapsulated ingredients. The company offers custom chemical product development and cGMP manufacturing, primarily serving the pharmaceutical, nutritional, and biotech industries.

Conroe, TX

Based in Conroe, TX, Lubchem Specialties provides custom chemical manufacturing services, specializing in toll blending and contract chemical blending. They offer outsourced production for chemical formulations, including various lubricants and specialized chemical products, leveraging their expertise and facilities for industrial clients.

Tomball, TX

Based in Tomball, TX, ManuSpec Company, Inc. provides chemical process development, piloting, and custom chemical and toll manufacturing services. They assist manufacturers, from large oil and chemical companies to startups, who need specialized chemical compounds and sophisticated materials. The company is ISO 9001:2000 certified.

MFG Chemical is a specialty chemical manufacturer offering custom manufacturing services. The company develops products from initial ideas to full production, utilizing upgraded plant facilities and world-class chemistry laboratories. They provide solutions for diverse markets, including water treatment, agriculture, energy, and personal care.

Arleta, CA

Based in Arleta, California, Miles Chemical Company specializes in liquid and dry chemical compound development. The company offers comprehensive toll blending and quality control services to industrial and commercial clients. They provide custom chemical manufacturing, formulation, and testing from their California facilities.

The Woodlands, TX

Based in The Woodlands, TX, Mission Chemical provides custom blending, packaging, and toll and contract manufacturing services. This full-service chemical company utilizes extensive in-house manufacturing and laboratory assets. They also offer chemical distribution, import, and export trade capabilities.

Houston, TX

Based in Houston, TX, Modern Chemical Co. provides comprehensive custom chemical manufacturing, chemical packaging, and bulk toll manufacturing services. They specialize in liquid and dry blending, filling, and chemical transloading for various liquid and powder substances. The company also operates as a bulk chemical distributor.

Pasadena, TX

Based in Pasadena, TX, Nippon Chemical Texas Incorporated (NCTI) is a custom chemical manufacturer. The company develops new chemical formulations, producing an expanding line of specialty chemicals known as Custom Products for global markets. NCTI also manufactures Ethylidene Norbornene (ENB) and Specialty Aromatic Solvents (SAS).

San Antonio, TX

Based in San Antonio, TX, Noah Chemicals provides custom chemical manufacturing services, specializing in high-purity and specialty chemicals. They offer bulk materials and packaging, covering a wide range of products including inorganics, metal salts, ceramics, rare earths, and pharmaceutical intermediates. The company also offers various chemical services.

Charlotte, NC

Based in Charlotte, NC, Northstar Chemical specializes in custom chemical blending solutions for diverse industrial applications. The company provides tailored options to meet specific specialty chemical requirements for its customers. Their services focus on delivering precision-blended chemical products.

Belle, WV

Based in Belle, WV, Optima Chemical provides custom chemical manufacturing services, spanning laboratory, kilo lab, pilot plant, and full-scale production. They specialize in organometallic chemistry and handling highly reactive, sensitive materials. Optima safely develops and scales new chemical entities for various industrial markets.

Warrington, PA

Based in Warrington, PA, Polysciences offers custom contract manufacturing solutions, including cleanroom filling, hazardous material handling, and custom blending for solids, liquids, and reagents. They provide pilot-scale to bulk production, cryogenic milling, and packaging services within ISO 7 and ISO 8 cleanroom environments.

Lower Gwynedd, PA

Richman Chemical Inc. provides custom synthesis and US-based manufacturing services. Based in Lower Gwynedd, PA, the company offers a full range of chemical solutions tailored for life science and chemical industry companies, supporting specialized chemical production needs with quality manufacturing.

Macedonia, OH

Royal Chemical Company, based in Macedonia, OH, specializes in custom chemical contract manufacturing. They offer liquid and powder toll blending, packaging, precision bottling, warehousing, and logistics services. With five U.S. plants, the company provides scalable operations for diverse industrial customers, including agrochemicals and cleaning products.

South Bend, IN

Based in South Bend, IN, Sandstrom Coating Technologies provides toll manufacturing for coating and adhesive producers. They process chemical raw materials into finished goods, adhering to client formulas and ISO 9001 standards. Their facility features tanks up to 5,000 gallons, mixers, and mills for custom blending and dispersing.

Ennis, TX

Based in Ennis, TX, Schirm USA is a chemical toll manufacturer specializing in custom formulation, packaging, and warehousing. They handle various product types, including liquids, powders, and granules, for industries such as agriculture, oil and gas, industrial additives, and janitorial products, utilizing facilities in Texas and Illinois.

Rosenberg, TX

Based in Rosenberg, TX, Seatex LLC is a specialty chemical technology manufacturing solutions company. They specialize in custom chemical manufacturing services, including reactions, liquid and dry blending, and grinding and milling. Seatex offers custom packaging from 1 gallon to rail car, serving agriculture, energy, and cleaning industries.

Pasadena, TX

Based in Pasadena, TX, SEKISUI Specialty Chemicals develops polymer solutions and creates specialty chemical products. The company utilizes its technologies and associates to produce sustainable solutions, including S-LEC B/K Polyvinyl Acetal Resin and PVOH, for diverse industrial and personal care applications.

Long Beach, CA

Established in 1951, Snyder Manufacturing specializes in chemical blending services. With three generations of experience, the company provides tailored blending solutions. It focuses on innovation and quality to meet various client needs.

Adelanto, CA

Based in Adelanto, CA, Specialty Organics, Inc. specializes in custom chemical synthesis and contract manufacturing. They provide tailored specialty chemicals, custom materials, and adhesive formulations, supporting clients from product development to full-scale production in their pilot plant. Services cater to diverse industries, including aerospace and high-tech consumer electronics.

Sauget, IL

Based in Sauget, IL, Stellar Manufacturing is a contract manufacturer specializing in solid particle chemical processing. Services include compaction granulation, briquetting, blending, and tableting for water treatment, agrochemical, and consumer products. The company handles difficult chemicals, including highly caustic or combustion hazards, transforming powders into marketable products.

Houston, TX

Based in Houston, TX, Sunita USA specializes in professional chemical toll blending and custom formulating services. Their state-of-the-art facilities, equipped with advanced liquid blending tanks and high-performance mixers, ensure precision and consistency in every batch. They develop custom solutions tailored to client product goals and industry standards for various sectors.

Sunland Chemical & Research Corporation offers custom chemical manufacturing services, including toll manufacturing, blending, bottling, and private label production. They handle various chemicals like acids, biocides, oxidizers, pesticides, and solvents. The company utilizes a state-of-the-art laboratory with HPLC and GC for rigorous quality and safety assurance.

Vernon, CA

Based in Vernon, CA, The Starco Group provides custom chemical manufacturing, material formulation, and private labeling services. They specialize in aerosol and bulk liquid chemicals for industrial, janitorial, automotive, food service, home care, personal care, and OTC pharma industries. Capabilities include bag-on-valve and canister aerosol technologies.

Houston, TX

Third Coast, based in Houston, TX, offers custom chemical contract manufacturing with over 20 years of experience. They provide dedicated production services, utilizing customer intellectual property to tailor products to exact specifications. Capabilities include reaction chemistry, filtration, and toll blending to support product commercialization.

Neptune City, NJ

Toll Compaction, based in Neptune City, NJ, offers comprehensive toll manufacturing services for powdered chemicals, polymer additives, nutritional products, and functional foods. Their capabilities include expert blending, repackaging, screening, pelletizing, dry granulation, and size reduction. The company operates facilities in New Jersey and West Virginia.

Dalton, GA

Based in Dalton, GA, TRCC specializes in custom chemical and specialty chemical manufacturing, including custom toll and contract services. The company delivers innovative solutions and technical expertise, serving markets such as carpet, flooring, textiles, healthcare, and oil & gas through its global manufacturing facilities.

Houston, TX

Based in Houston, TX, Verdant Specialty Solutions manufactures and supplies specialty chemicals. They provide custom formulations and solutions for diverse markets including personal care, home care & hygiene, industrial applications, and energy solutions like oil and gas production. Their focus is on delivering sustainable chemistry to meet client-specific B2B needs.

Brownwood, TX

Based in Brownwood, TX, VRC Technologies Inc. is a chemical company providing custom chemical manufacturing, toll blending, and chemical reaction capabilities. They also offer chemical storage, handling, and integrated logistics with rail and truck fleets. The company serves the oil & gas, agriculture, and broader chemicals industries.

Radnor, PA

Based in Radnor, PA, Nouryon is a global manufacturer of specialty chemicals, offering essential solutions for diverse industries. They provide a wide range of chemical products and ingredient solutions tailored for applications in textiles, leather, oilfield, and cleaning. The company focuses on innovation and expanding its production capabilities.

Santa Fe Springs, CA

Based in Santa Fe Springs, CA, Polynt Group manufactures a wide range of specialty chemicals. They produce and develop organic anhydrides, derivatives, intermediates, coating and composite resins, and thermoset compounds. Serving diverse industrial applications like automotive, aerospace, and medical, Polynt offers tailored chemical solutions and niche specialties.

Friendswood, TX

Based in Friendswood, TX, SONGWON Industrial Group manufactures specialty chemicals and additives for diverse industrial sectors. The company leverages advanced production processes and technology to tailor its chemical solutions to specific customer requirements, providing value through its products and supporting services.

Odessa, TX

Based in Odessa, TX, West Texas Blending specializes in custom chemical manufacturing, offering tailored solutions for liquid and dry blending. Services include transloading, packaging, and hazmat capabilities with flexible batch sizes. They serve industries such as agriculture, oil & gas, and water treatment, focusing on precision and reliability.

Avon, NY

Based in Avon, NY, Aldon Corporation specializes in contract chemical manufacturing for the chemical and life science sectors. They produce chemicals for scientific endeavors, offering custom chemical packaging, repacking, and filling services for liquids and powders, from small batches to large totes.

San Diego, CA

Based in San Diego, CA, Bio-Edge provides custom chemical production services, specializing in small-batch synthesis. They offer comprehensive R&D support for a range of client needs. The company caters to medical and industrial applications, delivering tailored chemical solutions for diverse product development and manufacturing projects.

Florence, KY

Based in Florence, KY, Camco Chemical is an experienced contract manufacturer and fulfillment provider for powder and liquid chemical products. With over 60 years of expertise, they offer chemical blending, packaging, warehousing, and bulk handling services. Camco supports diverse industries, simplifying supply chains with flexible batch sizes.

Decatur, TN

Based in Decatur, TN, Cymer Chemicals offers custom chemical and toll manufacturing services. They specialize in organic chemistries, producing high-purity specialty chemicals, polyamide-imide resins, and chemical additives. Their solutions enhance quality for industries like adhesives, aerospace, batteries, and coatings, ensuring robust and stable product performance.

LANXESS develops, manufactures, and markets chemical intermediates, additives, and specialty chemicals. The company focuses on creating solutions for consumer protection and industrial applications, including rubber additives and battery chemistry. They are expanding U.S. production capabilities to support diverse chemical needs.

Midland, TX

Based in Midland, TX, Obsidian Chemical provides custom chemical manufacturing services, specializing in toll blending. The company assists clients with complex chemical formulations, expertly mixing and processing batches into a final product. Their services support various industries requiring specialized chemical production.

Houston, TX

Based in Houston, TX, Riteks provides custom chemical manufacturing solutions for various industries. Since 1989, the company has partnered with businesses to offer comprehensive services including chemical manufacturing, blending, packaging, and repackaging. They focus on delivering reliable custom chemical solutions for their clients.

Houston, TX

South Coast Terminals provides toll blending services for chemical formulations, utilizing over 350 tanks across three Houston-area facilities in Texas. They offer comprehensive blending manufacturing, logistics, and planning support, helping clients outsource production needs efficiently and safely.

Pearland, TX

Based in Pearland, TX, SolvChem Custom Packaging (CPK) specializes in custom chemical blending, filling, and contract packaging services. They offer high-speed packaging for industrial and consumer chemicals into various containers, blending and distributing a wide selection of specialty, organic, and inorganic chemicals for manufacturers and marketers.

Pearland, TX

SolvChem Custom Packaging specializes in custom solvent blending and production, providing a wide range of chemical solvents for various applications. The company offers solvent packaging, warehousing, and logistic services for industrial and consumer customers, aiming to reduce overhead costs and ensure consistent quality.

Hebron, OH

Based in Hebron, OH, State Contract Manufacturing provides professional formula and process development services. They specialize in chemical blending, private labeling, material sourcing, and custom packaging solutions. The company offers comprehensive contract manufacturing expertise to meet diverse chemical production needs.

Mayfield Heights, OH

Based in Mayfield Heights, OH, State Industrial Products offers contract manufacturing services specializing in custom chemical formulation. Capabilities include liquid and powder blending, production, custom packaging, labeling, and logistics. The company supports a range of brands in bringing high-quality solutions to market.

Brownsville, TN

Based in Brownsville, TN, Teknor Apex Chemicals Division offers custom development and manufacturing services. They specialize in the design and synthesis of esters and other liquid organics, providing solutions from lab scale to full production.

Hillsboro, OR

Based in Hillsboro, Oregon, TOK America specializes in custom chemical manufacturing for advanced industries. They produce photoresists and auxiliary chemicals for semiconductor fabrication and medical devices. The company provides comprehensive toll manufacturing services, leveraging its facilities to produce custom chemical formulations for clients.

Woodlands, TX

Based in Woodlands, TX, Trecora provides custom chemical processing solutions. The company specializes in manufacturing high-purity specialty hydrocarbons, specialty waxes, and lubricant additives. They utilize their facilities to deliver tailored chemical compositions and specialized processing services for various industrial applications.

Independence, OH

Based in Independence, OH, Valtris Specialty Chemicals produces a range of specialty chemical additives, intermediaries, and precursors. The company focuses on providing solutions for the global polymers industry, continually expanding its offerings and collaborations to support industrial clients with essential chemical components.

Houston, TX

Based in Houston, TX, ALTIVIA is a chemical manufacturer offering custom chemical manufacturing services, including confidential toll and contract manufacturing. They produce a range of specialty chemicals, including phosgene derivatives, acetic acid, and acetic anhydride. ALTIVIA serves industrial clients, providing tailored chemical production solutions from their US facilities.

Halliburton offers chemical contract manufacturing and tolling services from its U.S. Gulf Coast facilities. The company manufactures and blends EO/PO-based chemistries, custom flammable blends, and multi-step reaction chemistries for various industries.

Cincinnati, OH

Based in Cincinnati, OH, Pilot Chemical develops and manufactures performance chemicals, offering custom and toll manufacturing services. They specialize in scaling processes from pilot to commercial production and product development. Proprietary technologies include alkylation, sulfonation, sulfation, and amidization, serving diverse industrial applications with reliable chemical supply.

Milwaukee, WI

Based in Milwaukee, WI, U.S. Lubricants provides toll blending services for a range of chemical products. They specialize in automotive, commercial, heavy-duty, industrial, and metalworking lubricants, along with various process chemical products.

Houston, TX

Based in Houston, TX, Vibrantz Technologies provides specialty chemicals and materials solutions, enhancing product safety, durability, and sustainability across countless applications. Leveraging expertise in particle engineering, glass, ceramic science, and color technology, the company engineers custom products and partners with customers on research and development.

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How to Choose a Company

  • Verify Process Chemistry Expertise and Equipment: Ensure the manufacturer has demonstrable experience with your specific reaction chemistry (e.g., organometallic, polymerization, fluorination, chiral separation) and the necessary reactor volumes, pressure/temperature ranges, and auxiliary unit operations like distillation columns, centrifuges, or dryers to handle your scale-up requirements effectively.
  • Evaluate Regulatory Compliance and Quality Systems: For pharmaceutical intermediates or APIs, strict adherence to cGMP (current Good Manufacturing Practices) and ICH Q7 guidelines is non-negotiable, alongside robust change control procedures. For medical device components, ISO 13485 certification may be required. If your product involves controlled substances, verify their DEA Schedule II-V licensing and robust security protocols.
  • Assess Scale-Up Capabilities and Flexibility: A significant red flag is a manufacturer without proven experience transitioning from pilot plant to commercial volumes, or one that offers vague proposals on critical process parameters. Demand detailed discussions on their approach to process hazard analysis (PHA), process safety management (PSM), and how they manage batch consistency as production scales, especially for custom formulations.
  • Examine IP Protection Protocols and Data Transparency: Scrutinize their non-disclosure agreements (NDAs) and manufacturing services agreements (MSAs) for clear intellectual property clauses. Be wary of manufacturers who are reluctant to provide comprehensive documentation, such as detailed Certificates of Analysis (CoA) with specified impurity limits, batch records, or process safety data sheets (PSDS) for critical intermediates.

Supplier Types at a Glance

TypeBest ForTypical MOQ
Contract Development & Manufacturing Organization (CDMO)Novel API synthesis, complex multi-step organic reactions, full-service process development and validation, regulatory filings (e.g., drug substance)Kilo-lab to multi-ton scale, often starting at small quantities for development
Specialty Chemical Custom SynthesizerNiche fine chemicals, proprietary intermediates, advanced materials, specific challenging reaction chemistries, less regulated markets100s of kgs to multi-ton batches
Toll Blender & FormulatorBlending liquid or powder formulations, simple mixing, packaging, established processes (e.g., industrial cleaners, lubricants, agricultural blends)Minimum 1-5 metric tons or 1,000+ gallons

Frequently Asked Questions

What is the key difference between a custom chemical synthesis partner and a toll manufacturer?

A custom chemical synthesis partner, often a CDMO, typically engages in complex, multi-step reaction chemistry to produce a novel or proprietary molecule according to a client's specific process and specifications. They bring process development expertise, analytical method validation, and often scale-up capabilities from lab to commercial scale. In contrast, a toll manufacturer primarily focuses on executing an established process or blending a formula provided entirely by the client. They offer their equipment and operational labor for a fee, with less involvement in process optimization or intellectual property development. Understanding this distinction is crucial for matching your project's technical needs and IP considerations with the right supplier.

How should I approach intellectual property protection when engaging a custom chemical manufacturer?

IP protection is paramount in custom chemical manufacturing. Beyond a robust non-disclosure agreement (NDA), ensure your manufacturing services agreement (MSA) clearly defines ownership of process improvements, analytical methods, and any newly developed IP during the engagement. For proprietary synthesis, consider a 'black box' approach where the manufacturer receives only the necessary reaction parameters without full disclosure of your end product's application or deeper chemistry. Additionally, inquire about their internal IP management policies, employee training, and physical security measures to safeguard your confidential information throughout the manufacturing process.

What critical documentation and data should I expect for a custom chemical batch?

For every custom chemical batch, you should expect comprehensive documentation to ensure traceability, quality, and regulatory compliance. This typically includes a Certificate of Analysis (CoA) detailing product specifications, testing methods, and actual results (including impurity profiles and residual solvents), along with the date of manufacture and expiry. Additionally, request detailed batch records, which document every step of the manufacturing process, raw material lot numbers, equipment used, in-process testing, and deviations. For critical raw materials, ask for their vendor CoAs. For highly regulated industries, a Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) specific to your final product should also be provided.

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